Tuesday, August 15, 2006

Protein Holds Promise as Tooth Regenerator

THURSDAY, June 29 (HealthDay News) -- Dental researchers say a specific protein may help a component of cavity-ridden teeth grow back, potentially preventing the need for root canals.
The findings are preliminary, and the synthetic protein, known as Dentonin, hasn't reached the required third level of testing, so it may be years before it gets approval to reach the market.
Still, Dentonin seems to have possibilities, said David Rosen, vice president of research and development at Acologix, the Hayward, Calif., company developing the product. "It's such a novel approach," he said. "There really isn't anything like it."
Dentonin is designed to help the teeth rebuild dentin, a bone-like hard tissue that forms between the outer enamel and the inner pulp, Rosen said.
When someone has a deep cavity, a dentist will drill through the enamel and dentin, Rosen said. In some cases, this causes sensitivity to hot and cold, and a root canal may be necessary because the nerve is exposed. Over time, the tooth dies and a dental implant may need to be inserted, he said.
In the new study, researchers from Acologix, the University of California, San Francisco and the University of Connecticut studied 35 patients scheduled to undergo at least two extractions of third molars. The researchers placed Dentonin on some of the soon-to-be-extracted teeth and a placebo compound on the others.
An analysis of the extracted teeth showed that Dentonin appeared to stimulate formation of new dentin. No side effects were reported. Apparently, the treatment stimulates cells in the pulp, which then produce dentin, Rosen said.
The researchers were to report their findings Thursday at the 84th general session of the International Association for Dental Research, in Brisbane, Australia.
"We're hoping we could use it in a situation when a dentist sees a cavity of any kind," said Rosen, adding that the protein may be most effective when someone has a deep cavity that threatens to expose the nerve.
However, the researchers still have to launch a larger phase III study to confirm that the treatment works. And Rosen cautioned that the new study doesn't prove that Dentonin could prevent root canals, although researchers hope it could at least prevent tooth sensitivity.
Dr. Dan Meyer, an associate executive director at the American Dental Association who's familiar with the study findings, said Dentonin "shows promise" as a way to regenerate dentin in a "healthier way."
"There's a long way to go yet, but hopefully this will pan out to be a very good product," he said.
Other dental products aim to help regenerate teeth that have been damaged by decay, he added.
More information
Learn more about tooth decay from the American Dental Association.

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