Saturday, August 27, 2011

Genome of Leukemia Patient Reveals Common Mutations

(HealthDay News) -- Decoding the genome of a man with acute myeloid leukemia (AML) revealed genetic mutations that may be common among other cancer patients.

Scientists at the Washington University School of Medicine in St. Louis detected one mutation that's common in brain tumors called gliomas and another that was found in a second patient with AML.

Neither of the mutations had been previously linked to leukemia. The fact that these mutations sometimes occur in other patients suggest they play a role in the development and progression of cancer, they said.

The researchers sequenced the genome of a man who was diagnosed with AML at age 38 and had been in remission for more than three years. He was selected for genome sequencing because he had typical clinical and molecular features of the disease, including two AML-related mutations already known to the researchers. Read more...

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