Wednesday, October 11, 2006

Developmental Damage & Toxic Metals

Effects of Toxic Metals on Learning Ability and Behavior

EDTA Detoxamin Therapy for Children
order here:

The human brain forms and develops over a long period of time compared to other organs, with neuron proliferation and migration continuing in the postnatal period. The blood-brain barrier is not fully developed until the middle of the first year of life. Similarly there is postnatal activity in the development of neuronal receptors and transmitter systems, as well as in the production of myelin. The fetus has been found to get significant exposure to toxic substances through maternal blood and across the placenta, with fetal levels of toxic metals often being higher than that of maternal blood.19,30-32,41-43

Likewise infants have been found to get significant exposure to toxics, such as mercury and organochlorine compounds that their mother is exposed to, through breast-feeding.26,30-32,43,101,107

The incidence of neurotoxic or immune reactive conditions such as autism, scizophrenia, ADD, dyslexia, learning disabilities, etc. have been increasing rapidly in recent years.2,80-82,143,14

A recent report by the National Research Council found that 50% of all pregnancies in the U.S. are now resulting in prenatal or postnatal mortality, significant birth defects, developmental neurological problems, or otherwise chronically unhealthy babies.82 There has been a similar sharp increase in developmental conditions in Canadian children132, including increases in learning disabilities and behavioral problems, asthma and allergies, and childhood cancer.

Exposure to toxic chemicals or environmental factors appear to be a factor in as much as 28 percent of the 4 million U.S. children born each year6-23, with at least 1 in 6 having one of the neurological conditions previously listed according to the U.S. Census Bureau.82 U.S. EPA estimates that over 3 million of these are related to lead or mercury toxicity.2,41,81,108 Evidence indicates that over 60,000 children are born each year with neurodevelopmental impairment due to methylmercury107, with even higher levels of exposure and impairment from two other sources, vaccines and mother's amalgam dental fillings.43,81

The level of exposure in most infants to mercury thimerosal has been found to be many times higher than the federal limits for mercury exposure.81,122 The largest increase in neurological problems has been in infants2,80-82, with an increase in autism cases to over 500,0002,80-82,43b, an over 500% increase to a level of almost 1 per 300 infants in the last decade80, making it the 3rd most common chronic childhood condition, along with similar increases in ADD2,41,43b, 83,88,143. According to the American Academy of Pediatrics between 4 to 12 % of all school age children are affected by ADHD144 and a similar number have some degree of dyslexia41. However large surveys of elementary level student records finds much higher levels- with over 20% of elementary school boys in some areas being treated for ADD.

143 Studies have found that long term use of stimulant drugs commonly causes significant adverse neurological and health effects145, and options are available to deal with such conditions without such adverse effects including dealing with the underlying causes.

Children's Exposure To Tobacco Smoke: Still A Health Threat
May Lower Vitamin C Levels, Increase Ear Infections
As every parent knows, kids are like sponges. They take in everything around them. Unfortunately, that often includes second-hand tobacco smoke.
More than 40% of children grow up in a household with at least one smoker. And two new studies suggest that environmental exposure to smoke could have detrimental health consequences for these children very early in life.

Richard S. Strauss, M.D., from the Department of Pediatrics at the University of Medicine and Dentistry of New Jersey - Robert Wood Johnson School Of Medicine, recently evaluated data from a sample of nearly 3000 children between the ages of 4 and 18. He found that as the amount of a nicotine metabolite, called cotinine, increased in the children's blood, their circulating levels of Vitamin C decreased.

"This report is the first large study to document direct metabolic consequences of environmental tobacco smoke in children," Dr. Strauss pointed out. Dr. Strauss noted that tobacco smoke is loaded with free radicals. Thus, ongoing exposure to second-hand smoke is likely to put greater stress on the children's antioxidant reserves, using up more of the available supply of Vitamin C. Such a relationship has already been shown in adults who smoke. The potential health effects could be serious, Dr. Strauss observes, because free radical stress can damage DNA in the cell. It can also create a more reactive, destructive form of cholesterol that promotes heart disease.

And there may be an even more immediate impact. Another recent study found that children exposed to second-hand tobacco smoke had a 38% higher rate of new ear infections (otitis media) than other children. The analysis was based on both personal smoking history of the family and the levels of cotinine measured in the children's urine.

"Passive smoking increases the risk of otitis media in children, and cotinine urinalysis is a reliable method to determine the effect of passive smoking," they concluded.
These study results contradict the assertion by the tobacco industry that second-hand smoke is not harmful, the researchers stated. They called for improved ways to protect children from the potential health threat posed by environmental tobacco smoke.146,147

2. U.S. Envinomental Protection Agency, Hazardous Air Pollutant Hazard Summary Fact Sheets, EPA: In Risk Information System, 1995; & EPA spokesman, U.S.News & World Report, "In the Air that they Breathe", Science & News, 12-20-99. & U.S. Environmental Protection Agency (EPA), 1996, "Integrated Risk Information System, National Center for Environmental Assessment, Cincinnati, Ohio (& webpage);& EPA spokesman, U.S.News & World Report, "Kids at Risk"(cover story), 6-19-2000;
6. Marlowe M, Cossairt A, Moon C. Errera J. "Main and Interactive Effects of Metallic Toxins on Classroom Behavior, Journal of Abnormal Child Psychology 1985; 13(2): 185-98. (6a) Marlowe,M Stellern J, Errera J, Moon C. Main and interaction effects of metal pollutants on visual-motor performance. Arch Environ Health 1985; 40(4):221-5.
7. Pihl RO, Parkes M. Hair element content in learning disabled children. Science 1977 Oct 14;198(4313):204-6.
8. Moon C, Marlowe M Stellem J, Errera J. "Main and Interactive Effects of Metallic Pollutants on Cognitive Functioning", Journal of Learning Disabilities 1985; 18(4):217-221.
9. Lewis M, Worobey J, Ramsay DS, McCormack MK. Prenatal exposure to heavy metals: effect on childhood cognitive skills and health status. Pediatrics 1992;89(6 Pt 1):1010-15.
10. Capel ID, Pinnock MH, Dorrell HM, Williams DC, Grant EC. Comparison of concentrations of some trace, bulk, and toxic metals in the hair of normal and dyslexic children. Clin Chem 1981 Jun;27(6):879-81; & Frith CD et al,Dyslexia more common in English speaking countries, Science, Mar 2001.
11. Marlowe M, Errera J, Jacobs J. Increased lead and cadmium burdens among mentally retarded children and children with borderline intelligence. Am J Ment Defic 1983 Mar;87(5):477-83; & Journal of Special Education 1982; 16:87-99.
12. Thatcher RW, Lester ML, McAlaster R, Horst R. Effects of low levels of cadmium and lead on cognitive functioning in children. Arch Environ Health 1982 May-Jun;37(3):159-66.
13. Marlowe M, Errera J, Cossairt A, Welch K. Hair mineral content as a predictor of learning disabilites. Journal of Learning Disabilites 1985.
14. Marlowe M, Errera J, Jacobs J. Increased lead and mercury levels in emotionally disturbed children. Journal of Orthomolecular Psychiatry 1983; 12: 260-267;& Journal of Abnormal Psychology 1983; 93:386-9.
15. Marlowe M, Moon C, Errera J, Jacobs J. Levels and combinations of metallic toxins and measures of behavioral disturbance. In: Rutherford RB(Ed.), Monographs in Behavior Disorders, Vol 5, p76-85; Council for Children and Behavior Disorders, Reston Va; & Chisolm J. Toxicity from heavy metal interactions and behavioral effects. Pediatrics 1974; 53:841-43.
16. Wecker L, Miller SB, Cochran SR, Dugger DL, Johnson WD. Trace element concentrations in hair from autistic children. Defic Res 1985; 29(Pt 1): 15-22; & Zhai ST, Trace element measurement in patients with scizophenia.Chung Hua Shen Ching Shen Ko Tsa Chih 1990, 23(6):332-8,383.
17. Rimland B, Larson GE. Hair mineral analysis and behavior: An analysis of 51 studies. Journal of Learning Disabilities 1983; 16: 279-85.
18. Jiang HM, Han GA, He ZL. Clinical significance of hair cadmium content in the diagnosis of mental retardation of children. Chin Med J (Engl) 1990 Apr;103(4):331-4.
19. Great Smokies Diagnostic Lab, Developmental Disorders of Toxic Origin: the Persistance of Lead, 2000,; & Emory E, Pattillo R, Archibold E, Bayorh M, Sung F, Neurobehavioral effects of low-level lead exposure in human neonates. Am J Obstet Gynecol 1999, 181: S2-11; & Mendelsohn AL, Dreyer BP, et al, Low-level lead exposure and behavior in early childhood. Pediatrics1998, 101(3): E10; & Chisolm JJ, O'Hara DM. Lead absorption in children. Baltimore, Maryland: Urban & Schwarzenberg, 1982.
20. Bonithon-Kopp C, Huel G, Moreau T, Wendling R. Prenatal exposure to lead and cadmium and psychomotor development of the child at 6 years. Neurolbehav Toxicol Teratol 1986; 8(3):307-10.(20a) David OJ, Hoffman SP, Sverd J, Clark K. Am J Psychiatry 1976; 133: 1155; & Perino J, Ernhart CB. Proc Annu Conv Am Psychol Assoc 1973; 81:719; & Leviton A, Bellinger D, Allred EN. Pre- and postnatal low-level lead exposure and children's disfunction in school. Environ Res 1993; 60(1): 30-43; & Eppright TD, Samfacon JA, and Horwitz EA. ADHD, infantile autism, and elevated blood level: a possible relationship. Mo Med 1996; 93(3):136-8; & Brockel BJ, Cory-Slechta DA. Lead, attention, and impulsive behavior. Pharmacol Biochem Behav 1998; 60(2):545-52; & Bellinger D et al, Attentional correlates of dentin levels in adolescents, Arch Environ Health 1994, 49(2):8-105.(20b) Deborah C. Rice. Parallels between Attention Deficit Hyperactivity Disorder and Behavioral Deficits Produced by Neurotoxic Exposure in Monkeys. Environmental Health Perspectives Volume 108, Supplement 3, June 2000
21. Needleman HL, Riess JA, Tobin MJ, Biesecker GE, Greenhouse JB; Bone lead levels and delinquent behavior. JAMA 1996, 275(5):363-9; & Needleman HL, Schell A, Bellinger D, Leviton A, Allred En. The long-term effects of exposure to low dose of lead in childhood, N. England Jr Med 1990, 322: 83-88; & Needleman HL, Leviton A, Reed R. Deficits in Psychologic and classroom performance of children with elevated dentine lead levels. New Eng J of Med 1979; 300: 689-95; & Burns JM, Baghurst PA, Sawyer MG, McMichael Am, Ton SL, Lifetime low- level lead exposure to environmental lead and children's emotional and behaviorial development at ages 11-13.Am J Epidemiology 1999, 149(8): 740-49.
22. Winneke G, Kramer U, et al. Neurolpsychological studies in children with elevated tooth lead. International Archives of Occupational Environmental Health, 1983; 51:231-252; & de la Burde B, Dhoate M. Early asymptomatic lead exposure and development at school age. Journal of Pediatrics 1975; 87: 638-642.
23. Nancy Hallaway, Zigurts Strauts, Turning Lead into Gold : How Heavy Metal Poisoning Can Affect Your Child and How to Prevent and Treat It, 1995; & Dr. Bruce Lanphear, Cincinnati Children's Hospital Medical Center, Annual Meeting of the Pediatric Academic Societies, Baltimore, April, 2001, ;
24. Albert RE, Shore RE, Sayers AJ, et al, Environmental Health Perspectives 1974; 7:33-40; & Annau Z, Cuomo V. Mechanisms of neurotoxicity and their relationship to behavioral changes. Toxicology 1988; 49(2-3): 219-25.
25. Needleman HL. Behavioral Toxicology. Environ Health Perspect 1995; 103(Supp6): 77-79; & (b) USPHS(ATSDR), Toxicological profile for lead. 1997. U.S. Public Health Service, CDROM.; & © Hu H. Heavy metal poisoning. In: Fauci AS, ed. Harrison's principles of internal medicine. New York, New York: McGraw-Hill, 1998:2565--6.
26. Abadin HG, Hibbs BF, Pohl HR, U.S. Department of Health, Division of Toxicology, Agency for Toxic Substances and Disease Registry. Breast-feeding exposure of infants to cadmium, lead, and mercury: a public health viewpoint. Toxicol Ind Health 1997; 13(4):495-517.
30. T.W. Clarkson et al, "Reproductive and Developmental Toxicity of Metals" , Scandinavian J. of Work & Environmental Health, 1985;11:145-154: & Anderson HA, Wolff MS. Environmental contaminants in human milk. J Expo Anal Environ Epidemiol 2000 Nov-Dec;10(6 Pt 2):755-60. 31. Lutz E, Lind B, Herin P, Krakau I, Bui TH, Vahter M. Concentrations of mercury, cadmium, and lead in brain and kidney of second trimester fetuses and Infants. Journal of Trace Elements in Medicine and Biology 1996;10: 61-67; & G.Drasch et al, "Mercury Burden of Human Fetal and Infant Tissues", Eur J Pediatr 153:607-610,1994; & A.Oskarsson et al, "Mercury in breast milk in relation to fish consumption and amalgam", Arch environ Health, 1996,51(3):234-41; & Drasch et al, "Mercury in human colostrum and early breast milk", J.Trace Elem. Med.Biol., 1998,12:23-27
32. Vahter M, Akesson A, Lind B, Bjors U, Schutz A, Berglund M. Longitudinal study of methylmercury and inorganic mercury in blood and urine of pregnant and lactating women, as well as in umbilical cord blood. Environ Res 2000 Oct;84(2):186-94
37. H.R. Casdorph, Toxic Metal Syndrome, Avery Publishing Group, 1995 & S.E. Levick, Yale Univ. School of Medicine, New England Journal of Medicine; July 17, 1980; & Muldoon SB et al, Effects of lead levels on cognitive function of older women, Neuroepidemiology, 1996, 15(2): 62-72; & Neddleman HL et al, The long-term effects of exposure to low doses of lead in childhood. N Eng J Med, 1990, 322(2):83-8; & Michael Smith, Woman's poison fillings blamed for attack on mother , The Daily Telegraph, 09-26-1998, pp14.
38. Atchison WD. Effects of neurotoxicants on synaptic transmission: lessons learned from electrophysiological studies. Neurotoxicol Teratol 1988 Sep-Oct;10(5):393-416.
39. P.Bulat, "Activity of Gpx and SOD in workers occupationally exposed to mercury", Arch Occup Environ Health, 1998, Sept, 71 Suppl:S37-9; & Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995; 18(2): 321-36.
40. Lopez-Ortal P, Souza V, Bucio L, Gonzalez E, Gutierrez-Ruiz M. DNA damage produced by cadmium in human fetal hepatic cell line. Mutat Res 1999 Feb 19;439(2):301-6.
41. Rodier P.M. Developing brain as a target of toxicity. Environ Health Perspect 1995; 103(Supp 6): 73-76; & Weiss B, Landrigan PJ. The developing brain and the Environment. Environmental Health Perspectives, Volume 107, Supp 3, June 2000; & Frith CD et al, More Dyslexia in English Speaking Countries, Science, Mar 2001.
42. Rice, DC, Issues in developmental neurotoxicology: interpretation and implications of the data. Can J Public Health 1998; 89(Supp1): S31-40; & Rice DC, Barone S, Critical Periods of Vulnerability for the Developing Nervous System: Evidence from human and animal models. Environ Health Persect 2000, 108(supp 3):511-533; & © A research-orientated framework for risk assessment and prevention of exposure to environmental toxicants; Environ Health Perspectives, 1999, 107(6): 510.
43. B. Windham, Annotated Bibliography: Health Effects Related to Mercury from Amalgam Fillings and Documented Clinical Results of Replacement of Amalgam Fillings" 2001. (over 800 references & 60,000 clinical cases);& (b) B.Windham, Common Exposure Levels and Developmental Effects of Mercury in Infants, 2001;
57. Petit TL, et al, Early lead exposure and the hippocampus. Neurotoxicology 1983; 4(1): 80. California Health and Human Services Agency, Dept. Of Developmental Services, April 16, 1999 and June 2000; & Special Education Census Data: 1993-98, State of Maryland Dept. Of Education, 1999 & (b) Yazbak FE(MD, FAAP) Autism 99 : A National Emergency,; & © Gary Null, Second Opinion: Vaccinations, Gary Null and Associates, Inc. 2000, & (d)"Advocacy Groups Call for Research to Investigate Link Between Autism Increase and Vaccination", April 16,1999: Autism Research Institute, Cure Autism Now, Autism Autoimmunity Project, and National Vaccine Information Center;
81. Autism: a unique form of mercury poisoning. & Halsey, NA. Limiting Infant Exposure to Thimerosal in vaccines. J. of the Amer. Medical Assoc., 282: 1763-66; & Edelson SB, Cantor DS. Autism: xenobiotic influences. Toxicol Ind Health 1998; 14(4): 553-63; & A. Holmes,
82. National Academy of Sciences, National Research Council, Committee on Developmental Toxicology, Scientific Frontiers in Developmental Toxicology and Risk Assessment, June 1, 2000, 313 pages; & Evaluating Chemical and Other Agent Exposures for Reproductive and Developmental Toxicity Subcommittee on Reproductive and Developmental Toxicity, Committee on Toxicology, Board on Environmental Studies and Toxicology, National Research Council National Academy Press, 262 pages, 6 x 9, 2001; & National Environmental Trust (NET), Physicians for Social Responsibility and the Learning Disabilities Association of America, "Polluting Our Future: Chemical Pollution in the U.S. that Affects Child Development and Learning" Sept 2000;
83. Great Smokies Diagnostic Lab, Depression, ADD & ADHD research web pages (click on: by condition),research studies on causes and treatments, http://; & Dr. G. Klerman, National Institute of Health, Factors in the rapid rise of depression, 1997; & ADD case study, & Tuthill RW, Hair lead levels related to children's classroom attention-deficit behavior. Arch Environ Health, 1996, 51(3):214-20.
88. Barlow PJ. A pilot study on the metal levels in hair of hyperactive children. Med Hypotheses 1983, 11(3): 309-18; & Pfieffer CC, Braverman ER. Zinc, the brain and behavior. Biol Psychiat 1982, 17(4):513-32;
101. Grandjean P; Jurgensen PJ; Weihe P. Milk as a Source of Methylmercury Exposure in Infants. Milk as a Source of Methylmercury Exposure in Infants. Environ Health Perspect 1994 Jan;102(1):74-7; & Watanabe C, Satoh H. Evolution of our understanding f methylmercury as a health threat. Environ Health Perspect
107. Science News, Methylmercury's toxic toll. July 29, 2000, Vol 158, No.5, p77; & National Research Council, Toxicological Effects of Methylmercury, National Acadamy Press, Wash, DC, 2000; & Grandjean P, 2000, Health effects of seafood contamination with methylmercury and PCBs in the Faroes. Atlantic Coast Contaminants Workshop, June 22-25, 2000, Bar Harbor Maine.
108. US. Dept. of Health, ATSDR, ; & U.S. EPA, Lead in your drinking water, 1993,; & U.S. Centers for Disease Control, Childhood lead poisoning in the U.S. 1997, & Screening Young Children for Lead Poisoning. Atlanta, GA:Centers for Disease Control and Prevention, 1997. & Neilke HW, Reagan PL, Soil is an important pathway of human lead exposure. Environ Health perspect 1998, 106:217-29.
122. Dr Thomas Verstraeten, US Centres for Disease Control and Prevention, Summary Results: Vaccine Safety Datalink Project - a database of 400,000 children , May 2000.
132.The Health of Canada's Children--A Canadian Institute of Child Health (CICH), Profile: 3rd Edition, 2000, 325 pages.
143. The extent of drug therapy for attention deficit-hyperactivity disorder among children in public schools. (American Journal of Public Health. 1999; 89(9):1359-64)
144. American Acadamy of Pediatrics, American J of Psychiatry, 2000, 157:1077-1083; & American Acadamy of Pediatrics, Report to Clinicians;
145. Adverse health effects of Ritalin and other stimulant drugs:; &; &
146. Strauss RS. Environmental tobacco smoke and serum vitamin C levels in children. Pediatrics 2001;107(3):540-42.
147. Ilicali OM, Keles N, Deger K, Sagun OF, Guldiken Y. Evaluation of the effect of passive smoking on otitis media in children by an objective method: urinary cotinine analysis. Laryngoscope 2001;111:163-67.

more discussion: Forum
· Addiction Forum · Ask the Doctors Forum · Ayurveda Forum · Ayurvedic & Thai Herbs Forum · Colon Cleansing Forum · Dental Forum · Diabetes Forum · Diet Forum · General Cleansing Forum · Hepatitis A, B. C Forum · Integrated Medicine Forum · Live Blood Analysis Forum · Ozone-Oxygen-Forum · pH - Alkaline - Acidity Forum · Weight Loss Forum

No comments:

Dr. Group's Secret to Health Kit

Dr. Group's Secret to Health Kit

[ learn more ]

Add to Cart

Dr. Group's Secret to Health Kit offers simple at-home solutions for cleansing internally and externally thereby reducing toxins, restoring the body's natural healing process, and helping you achieve true health and happiness.

Advanced Body Cleansing Kit

Advanced Body Cleansing Kit

[ learn more ]

Add to Cart

Advanced Body Cleansing Kit with Livatrex™, Oxy-Powder®, Latero-Flora™ and two bottles of ParaTrex®.